How do patients from South Asian backgrounds experience life on haemodialysis in the UK? : A multicentre qualitative study

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.OBJECTIVES: End-stage kidney disease disproportionately affects people of South Asian origin. This study aimed to uncover the lived experiences of this group of patients on centre-based haemodialysis (HD), the most prevalent dialysis modality. DESIGN: The study utilised a qualitative focus group methodology. Seven focus groups were conducted across four NHS Trusts in the UK including three in Gujarati and two each in Punjabi and Urdu. This provided an inclusive opportunity for South Asian patients to contribute in their language of origin. A total of 24 patients participated. Focus groups were facilitated by bilingual project workers and data were forward translated and analysed using thematic analysis. RESULTS: Four themes were identified. This included (1) 'treatment imposition', which comprised of the restrictive nature of HD, the effects of treatment and the feeling of being trapped in an endless process. (2) The 'patient-clinician relationship' centred around the impact of a perceived lack of staff time, and inadequacies in the quality of interactions. (3) 'Coping strategies' highlighted the role of cognitive reappraisal, living in the moment and family support networks in facilitating adjustment. (4) 'Pursuit of transplantation' included equating this form of treatment with restoring normality, alongside cultural factors limiting hopefulness for receiving an organ. CONCLUSIONS: In general, the experiences of South Asian patients receiving HD were not unique to this ethnic group. We did find distinct issues in relation to interactions with healthcare professionals, views on access to transplantation and the importance of family support networks. The study provides useful insights which may help enhance culturally tailored renal care.Peer reviewe

A new method of measuring the cluster peculiar velocity power spectrum

We propose to use spatial correlations of the kinetic Sunyaev-Zeldovich (KSZ) flux as an estimator of the peculiar velocity power spectrum. In contrast with conventional techniques, our new method does not require measurements of the thermal SZ signal or the X-ray temperature. Moreover, this method has the special advantage that the expected systematic errors are always sub-dominant to statistical errors on all scales and redshifts of interest. We show that future large sky coverage KSZ surveys may allow a peculiar velocity power spectrum estimates of an accuracy reaching ~10%.Comment: 5 pages, 2 figures, MNRAS in Press (doi: 10.1111/j.1365-2966.2008.13454.x

Cosmic Flows on 100 Mpc/h Scales: Standardized Minimum Variance Bulk Flow, Shear and Octupole Moments

The low order moments, such as the bulk flow and shear, of the large scale peculiar velocity field are sensitive probes of the matter density fluctuations on very large scales. In practice, however, peculiar velocity surveys are usually sparse and noisy, which can lead to the aliasing of small scale power into what is meant to be a probe of the largest scales. Previously, we developed an optimal ``minimum variance'' (MV) weighting scheme, designed to overcome this problem by minimizing the difference between the measured bulk flow (BF) and that which would be measured by an ideal survey. Here we extend this MV analysis to include the shear and octupole moments, which are designed to have almost no correlations between them so that they are virtually orthogonal. We apply this MV analysis to a compilation of all major peculiar velocity surveys, consisting of 4536 measurements. Our estimate of the BF on scales of ~ 100 Mpc/h has a magnitude of |v|= 416 +/- 78 km/s towards Galactic l = 282 degree +/- 11 degree and b = 6 degree +/- 6 degree. This result is in disagreement with LCDM with WMAP5 cosmological parameters at a high confidence level, but is in good agreement with our previous MV result without an orthogonality constraint, showing that the shear and octupole moments did not contaminate the previous BF measurement. The shear and octupole moments are consistent with WMAP5 power spectrum, although the measurement noise is larger for these moments than for the BF. The relatively low shear moments suggest that the sources responsible for the BF are at large distances.Comment: 13 Pages, 7 figures, 4 tables. Some changes to reflect the published versio

Early Ultraviolet Observations of Type IIn Supernovae Constrain the Asphericity of Their Circumstellar Material

© 2020. The American Astronomical Society. All rights reserved.. We present a survey of the early evolution of 12 Type IIn supernovae (SNe IIn) at ultraviolet and visible light wavelengths. We use this survey to constrain the geometry of the circumstellar material (CSM) surrounding SN IIn explosions, which may shed light on their progenitor diversity. In order to distinguish between aspherical and spherical CSM, we estimate the blackbody radius temporal evolution of the SNe IIn of our sample, following the method introduced by Soumagnac et al. We find that higher-luminosity objects tend to show evidence for aspherical CSM. Depending on whether this correlation is due to physical reasons or to some selection bias, we derive a lower limit between 35% and 66% for the fraction of SNe IIn showing evidence for aspherical CSM. This result suggests that asphericity of the CSM surrounding SNe IIn is common - consistent with data from resolved images of stars undergoing considerable mass loss. It should be taken into account for more realistic modeling of these events

Average luminosity distance in inhomogeneous universes

The paper studies the correction to the distance modulus induced by inhomogeneities and averaged over all directions from a given observer. The inhomogeneities are modeled as mass-compensated voids in random or regular lattices within Swiss-cheese universes. Void radii below 300 Mpc are considered, which are supported by current redshift surveys and limited by the recently observed imprint such voids leave on CMB. The averaging over all directions, performed by numerical ray tracing, is non-perturbative and includes the supernovas inside the voids. Voids aligning along a certain direction produce a cumulative gravitational lensing correction that increases with their number. Such corrections are destroyed by the averaging over all directions, even in non-randomized simple cubic void lattices. At low redshifts, the average correction is not zero but decays with the peculiar velocities and redshift. Its upper bound is provided by the maximal average correction which assumes no random cancelations between different voids. It is described well by a linear perturbation formula and, for the voids considered, is 20% of the correction corresponding to the maximal peculiar velocity. The average correction calculated in random and simple cubic void lattices is severely damped below the predicted maximal one after a single void diameter. That is traced to cancellations between the corrections from the fronts and backs of different voids. All that implies that voids cannot imitate the effect of dark energy unless they have radii and peculiar velocities much larger than the currently observed. The results obtained allow one to readily predict the redshift above which the direction-averaged fluctuation in the Hubble diagram falls below a required precision and suggest a method to extract the background Hubble constant from low redshift data without the need to correct for peculiar velocities.Comment: 34 pages, 21 figures, matches the version accepted in JCA

A New Heavy Flavor Program for the Future Electron-Ion Collider

The proposed high-energy and high-luminosity Electron-Ion Collider (EIC) will provide one of the cleanest environments to precisely determine the nuclear parton distribution functions (nPDFs) in a wide $x$-$Q^{2}$ range. Heavy flavor production at the EIC provides access to nPDFs in the poorly constrained high Bjorken-$x$ region, allows us to study the quark and gluon fragmentation processes, and constrains parton energy loss in cold nuclear matter. Scientists at the Los Alamos National Laboratory are developing a new physics program to study heavy flavor production, flavor tagged jets, and heavy flavor hadron-jet correlations in the nucleon/nucleus going direction at the future EIC. The proposed measurements will provide a unique way to explore the flavor dependent fragmentation functions and energy loss in a heavy nucleus. They will constrain the initial-state effects that are critical for the interpretation of previous and ongoing heavy ion measurements at the Relativistic Heavy Ion Collider and the Large Hadron Collider. We show an initial conceptual design of the proposed Forward Silicon Tracking (FST) detector at the EIC, which is essential to carry out the heavy flavor measurements. We further present initial feasibility studies/simulations of heavy flavor hadron reconstruction using the proposed FST.Comment: 6 pages, 5 figures, proceedings for the XLIX International Symposium on Multiparticle Dynamics (ISMD2019) (9-13 September 2019) conferenc

The correlation between C/O ratio, metallicity and the initial WD mass for SNe Ia

In this paper, we want to check whether or not the carbon abundance can be affected by initial metallicity. We calculated a series of stellar evolution. We found that when $Z\leq0.02$, the carbon abundance is almost independent of metallicity if it is plotted against the initial WD mass. However, when $Z>0.02$, the carbon abundance is not only a function of the initial WD mass, but also metallicity, i.e. for a given initial WD mass, the higher the metallicity, the lower the carbon abundance. Based on some previous studies, i.e. both a high metallicity and a low carbon abundance lead to a lower production of $^{\rm 56}$Ni formed during SN Ia explosion, the effects of the carbon abundance and the metallicity on the amount of $^{\rm 56}$Ni are enhanced by each other, which may account for the variation of maximum luminosity of SNe Ia, at least qualitatively. Considering that the central density of WD before supernova explosion may also play a role on the production of $^{\rm 56}$Ni and the carbon abundance, the metallicity and the central density are all determined by the initial parameters of progenitor system, i.e. the initial WD mass, metallicity, orbital period and secondary mass, the amount of $^{\rm 56}$Ni might be a function of the initial parameters. Then, our results might construct a bridge linking the progenitor model and the explosion model of SNe Ia.Comment: 7pages, 4 figures, accepted for publication in A&

The luminosity of supernovae of type Ia from TRGB distances and the value of H_0

Distances from the tip of the red-giant branch (TRGB) in the halo Population of galaxies - calibrated through RR Lyr stars as well as tied to Hipparcos parallaxes and further supported by stellar models - are used to determine the luminosity of six nearby type Ia supernovae (SN 2011fe, 2007sr, 1998bu, 1989B, 1972E, and 1937C). The result is M_V^corr = -19.41 +/- 0.05. If this value is applied to 62 SNe Ia with 3000< v < 20,000 km/s a large-scale value of the Hubble constant follows of H_0 = 64.0 +/- 1.6 +/- 2.0. The SN HST Project gave H_0 = 62.3 +/- 1.3 +/- 5.0 from ten Cepheid-calibrated SNe Ia (Sandage et al. 2006). The agreement of young Population I (Cepheids) and old, metal-poor Population II (TRGB) distance indicators is satisfactory. The combined weighted result is H_0 = 63.7 +/- 2.3 (i.e. +/-3.6%). The result can also be reconciled with WMAP5 data (Reid et al. 2010).Comment: 9 pages, 3 figures, 3 tables, accepted for publication in Astronomy and Astrophysic

5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels.

AbstractWe recently identified a class of neuronal gene inheriting high levels of intragenic methylation from the mother and maintaining this through later development. We show here that these genes are implicated in basic neuronal functions such as post-synaptic signalling, rather than neuronal development and inherit high levels of 5mC, but not 5hmC, from the mother. 5mC is distributed across the gene body and appears to facilitate transcription, as transcription is reduced in DNA methyltransferase I (Dnmt1) knockout embryonic stem cells as well as in fibroblasts treated with a methyltransferase inhibitor. However in adult brain, transcription is more closely associated with a gain in 5hmC, which occurs without a measurable loss of 5mC. These findings add to growing evidence that there may be a role for 5mC in promoting transcription as well as its classical role in gene silencing

Consistently Large Cosmic Flows on Scales of 100 Mpc/h: a Challenge for the Standard LCDM Cosmology

Peculiar velocity surveys have non-uniform spatial distributions of tracers, so that the bulk flow estimated from them does not correspond to that of a simple volume such as a sphere. Thus bulk flow estimates are generally not strictly comparable between surveys, even those whose effective depths are similar. In addition, the sparseness of typical surveys can lead to aliasing of small scale power into what is meant to be a probe of the largest scales. Here we introduce a new method of calculating bulk flow moments where velocities are weighted to give an optimal estimate of the bulk flow of an idealized survey, with the variance of the difference between the estimate and the actual flow being minimized. These "minimum variance" estimates can be designed to estimate the bulk flow on a particular scale with minimal sensitivity to small scale power, and are comparable between surveys. We compile all major peculiar velocity surveys and apply this new method to them. We find that most surveys we studied are highly consistent with each other. Taken together the data suggest that the bulk flow within a Gaussian window of radius 50 Mpc/h is 407 km/s toward l=287 and b=8. The large-scale bulk motion is consistent with predictions from the local density field. This indicates that there are significant density fluctuations on very large scales. A flow of this amplitude on such a large scale is not expected in the WMAP5-normalized LCDM cosmology, for which the predicted one-dimensional r.m.s. velocity is ~110 km/s. The large amplitude of the observed bulk flow favors the upper values of the WMAP5 error-ellipse, but even the point at the top of the WMAP5 95% confidence ellipse predicts a bulk flow which is too low compared to that observed at >98% confidence level.Comment: 19 Pages, 7 Figures, MNRAS in Press. Added some references and text to reflect post proofs manuscrip